Fig. 1

Time course changes of body weight (A) and blood glucose (B) in control (Con) and exenatide-treated (Exe) db/db mice. OGTT (C), fasting insulin (D), HOMA-IR (E), HOMA-β (F), representative HE micrographs of pancreatic insulitis (G), and the percentage of insulitis scores of pancreatic islets (H) in Con and Exe group before and after 8-week treatment. Data are presented as mean ± SEM, n = 8 in each group; **P < 0.01,*P < 0.05 vs control (A, B), control 8 week (C), or control 0 week (D–F); & P < 0.01, ^#P < 0.05 vs control 8 week (D–F); ns P > 0.05. Scale bar = 50 μm. The black arrow indicates infiltrated cells. OGTT oral glucose tolerance test, HOMA-IR homeostasis model assessment of insulin resistance, HOMA-β homeostatic model assessment of β cell function