Table 1 Comparing peptidomimetics attributes with native peptides
Characteristics | Peptides | Peptidomimetics | References |
|---|---|---|---|
Stability | Limited stability toward proteolysis | Higher stability toward proteolysis | Trabocchi (2019), Li Petri et al. (2022), Trabocchi and Guarna (2014) |
Interactions/ Specificity | ✓ Low selectivity due to high backbone flexibility ✓ Interaction with multiple targets | ✓ Higher receptor affinity and selectivity ✓ Pharmacophore-based target selection | |
Transport system | Rapid excretion, poor cell permeability, lacks specific transport systems due to its relatively high molecular mass | ✓ Transports from Peptide transporter 2 (PEPT2) which is a low-capacity/high-affinity proton-coupled cotransporter of diverse di- and tripeptides ✓ The di/tripeptide transporter in the small intestine absorbs some of them | |
Activity | Limited activity | Higher activity | Kim et al. (2015) |
Duration of action | Shorter duration of action | longer duration of action |