Table 1 Biological function of gut microbiota in zebrafish
From: Zebrafish: an efficient vertebrate model for understanding role of gut microbiota
Biological function | Intestinal bacteria | Molecular mechanism | Reference |
|---|---|---|---|
Development | Aeromonas veronii biovar sobria, Pseudomonas fluorescens | Promoting intestinal epithelial maturation through distinct host recognition pathways | Bates et al. 2006 |
Gut microbiota | Determining the fate of intestinal epithelial secretory cells through Myd88-dependent inhibition of Notch signaling | Troll et al. 2018 | |
Aeromonas veronii HM21 | Enhancing the stability of β-catenin in intestinal epithelial cells and promoting cell proliferation in the development of vertebrate intestine | Cheesman et al. 2011 | |
Aeromonas veronii HM21, Shewanella | Releasing BefA protein that causes the multiplication of pancreatic β cells | Hill et al. 2016 | |
Aeromonas veronii: dTomato HM21, Vibrio cholerae:GFP ZWU0020 | Being required for normal neurobehavioral development in early life of zebrafish | Phelps et al. 2017 | |
Vibrio | Excessive growth of Vibrio species inhibit the development of adaptive immunity in larval zebrafish | Brugman et al. 2014 | |
Reproduction | Lactobacillus rhamnosus IMC 501 | Promoting gonadal differentiation through the regulation of GnRH and IGF signalings | |
Lactobacillus rhamnosus IMC 501 | Regulating ovary physiology by inhibiting follicular apoptosis and increasing follicular survival | Gioacchini et al. 2013) | |
Lactobacillus rhamnosus IMC 501 | Promoting follicle maturation and fecundity by modulating the gene expression of neuropeptide hormones and metabolic signals | ||
Pediococcus acidilactici | As a probiotic supplement in male zebrafish diet for the improvement of molecular parameters in testicular cells | Valcarce et al. 1887 | |
The commercial probiotic mixture SLAb51 | Counteracting the adverse effects of BPA on zebrafish reproduction by interacting with gametogenesis-related genes | Giommi et al. 2021 | |
Immunity | Aeromonas veronii biovar sobria, Pseudomonas fluorescens, Streptococcus, and Staphylococcus | Influencing host immunity through the regulation of Myd88 and TNF receptor | Bates et al. 2007 |
Exiguobacterium ZWU0009, Chryseobacterium ZOR0023 | Inducing changes in intestinal leukocyte subsets and Myd88-dependent gene expression of host | Koch et al. 2018 | |
Gut microbiota | Induces expressions of proinflammatory and antiviral factors, which results in the increased resistance of larvae to viral infection | Galindo-Villegas et al. 2012 | |
Gut microbiota | Suppressing systemic neutrophil activation by microbiota-induced Serum amyloid A | Murdoch et al. 2019 | |
Pseudomonas aeruginosa PAK | Regulating dynamic temporal and spatial transcription activation of NF-кB and subsequent up-regulation of target genes in intestine | Kanther et al. 2011 | |
Lactobacillus | Adhesive probiotic Lactobacillus has anti-infective in protecting zebrafish against pathogenic infections, which is correlated with their spatial distribution in the intestine | He et al. 2017 | |
Chryseobacterium massiliae | Protecting zebrafish from intestinal damage upon Flavobacterium columnare infection | Stressmann et al. 2021 | |
Metabolism | Aeromonas hydrophila (ATCC 35654), Pseudomonas aeruginosa PA01 | Modulating cholesterol metabolism and trafficking through the regulation of ApoB and Fdps | Rawls et al. 2004 |
Gut microbiota | Promoting the uptake of macromolecular proteins in the distal intestine | Bates et al. 2006 | |
Exiguobacterium sp. ZWU0009, Chryseobacterium sp. ZOR0023, Pseudomonas sp.ZWU0006 | Stimulating fatty acids uptake and lipid droplet accumulation in intestinal epithelia and liver | Semova et al. 2012 | |
Gut microbiota | Regulating expression of intestinal Angptl4 and storage of peripheral fat by suppressing the intestine-specific transcriptional enhancer | Camp et al. 2012 | |
Gut microbiota | Increasing lipid accumulation in intestinal epithelia by regulating gene expression related to lipid metabolism | Sheng et al. 2018 | |
Stenotrophomonas maltophilia, Enterococcus faecalis | The mouse high fat-diet-associated microbiota accelerate hyperlipidaemic phenotype in zebrafish embryos | Manuneedhi Cholan et al. 2022 | |
SCFAs | SCFAs produced by zebrafish microbiota reduces liver phosphoenolpyruvate carboxykinase 1 expression and overall glucose level | Han 2018 | |
Behavior | Aeromonas veronii: dTomato HM21, Vibrio cholerae:GFP ZWU0020 | Being necessary for locomotor activity of zebrafish larvae | Phelps et al. 2017 |
Lactobacillus plantarum | Modulating communication with CNS via microbiome-gut-brain axis |