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Table 3 Correlation matrix between the studied autophagy markers, HOMA-IR, HbA1C and the degree of albuminuria

From: Clinical application of RUBCN/SESN2 mediated inhibition of autophagy as biomarkers of diabetic kidney disease

 

Serum RUBCN

serum SESN2

serum mTOR

RUBCN expression

SESN2 expression

r

r

r

r

r

HOMA IR

0.670*

− 0.733*

0.825*

0.751*

− 0.798*

HbA1C

0.707*

− 0.746*

0.859*

0.791*

− 0.830*

ACR

0.925*

− 0.830*

0.867*

0.946*

− 0.897*

Serum RUBCN

1

− 0.863*

0.854*

0.940*

− 0.902*

serum SESN2

− 0.863*

1

− 0.859*

− 0.895*

0.872*

serum mTOR

0.854*

− 0.859*

1

0.923*

− 0.922*

RUBCN expression

0.940*

− 0.895*

0.923*

1

− 0.948*

SESN2 expression

− 0.902*

0.872*

− 0.922*

− 0.948*

1

  1. *indicates statistical significance (P < 0.05); r = Pearson correlation coefficient. All calculated P were significant < 0.001
  2. HOMA-IR: Homeostatic Model Assessment of Insulin Resistance; HbA1C; Glycated hemoglobin; ACR: Albumin/Creatinine ratio in urine; RUBCN: Rubicon; SESN2: Sestrin2; mTOR: mammalian target of Rapamycin
  3. Pearson’s correlation test was used