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Fig. 7 | Molecular Medicine

Fig. 7

From: Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Fig. 7

Cell differentiation trajectory and gene expression alteration of VSMCs and neutrophils. A CytoTRACE predicted the cell differentiation potential of VSMCs. B Genes correlated with more differentiated and less differentiated VSMCs predicted by CytoTRACE. C Pseudo-time analysis showed the cell differentiation trajectory of VSMCs based on selecting VSMCs 1 as the initiate. D, E heatmap of gene expression alteration relating to D ECM organization, cell adhesion and E response to stimulus. F Alteration curves of representative genes. The full line represented cell fate 1, the dashed line represented cell fate 2. G CytoTRACE predicted the cell differentiation potential of neutrophils. H Genes correlated with more differentiated and less differentiated neutrophils predicted by CytoTRACE. I pseudo-time analysis showed the cell differentiation trajectory of neutrophils upon selecting Neu 8 as the initiate. J, K heatmap of gene expression alteration relating to J chemotaxis, inflammatory and immune response and K cellular component movement. L Alteration curves of represented genes. The full line represented cell fate 1, the dashed line represented cell fate 2

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Molecular Medicine

ISSN: 1528-3658