Table 1 VSMC regulation by Transcription factor in response to atherosclerosis
From: Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis
TFs | Regulation | Targets | Effects on VSMC |
|---|---|---|---|
KLF4 | ↑ | α-SMA, SM22α, TAGLN, MYH11, LGALS3, OCT4, MYOCD, P21, Col 8A1, RUNX2 | Phenotypic transformation, foam cell, proliferation, migration, calcification |
KLF2 | ↑ | MYH11, OCT4 | Phenotypic transformation |
KLF5 | ↑ | MYH11, OCT4, miR-29a, BCL-2 | Phenotypic transformation, proliferation, migration, apoptosis |
KLF15 | ↓ | p300 | Phenotypic transformation |
NF-κB | ↑ | KLF4, CXCL13, CCL19, VCAM1, ICAM1, LOX-1, cyclin B1, CDK1, IL-6, ANKH, ALP | Phenotypic transformation, foam cell, proliferation, migration, calcification |
MYOCD | ↓ | α-SMA, SM22α, SMMHC, CNN1, SMMLCK, CD68, ABCA1, LOX-1, p65, miR-1 | Phenotypic transformation, foam cell, proliferation, migration |
OCT4 | ↑ | MYH11, MMP-3, MMP-13 | Phenotypic transformation, migration |
TCF21 | ↑ | TAGLN, CNN1, ACTA2, SCA1, LGALS3, SRF, MYOCD, MMP-1, MMP-3 | Phenotypic transformation, proliferation, migration |
PTEN | ↓ | SRF, PI3K, MCP-1, p70, NF-κB, caspase-3 | Phenotypic transformation, proliferation, migration, apoptosis, calcification |
NRF2 | ↓ | HO-1, NQO-1 | Phenotypic transformation, proliferation, migration, calcification |
CHOP | ↑ | KLF4, BCL-2, BIM, ERO1-α, PiT-1 | Proliferation, calcification, apoptosis |
FOXO | ↑ | CYR61, MMP-2, MMP-13, TIMP-1, TIMP-2, TIMP-3, BIM, APAF1, RUNX2 | Proliferation, migration, apoptosis, calcification |
GAX | ↓ | Integrinα2 | Phenotypic transformation |
SP1 | ↑ | KLF4, TRAIL, MMP-9 | Proliferation, migration, apoptosis |
NFAT5 | ↑ | α-SMA, SOD1, PLIN2, FABP3, PPARD, ABCA1 | Phenotypic transformation, foam cell, migration |
STAT | ↑ | cyclin D1, survivin, RUNX2, miR-92a, LOXL1-AS1, MMP-2, ICAM-1, IP-10, RUNX2 | Phenotypic transformation, proliferation, migration, calcification |
PAX9 | ↑ | α-SMA, SM22α, PCNA, MMP-2, MMP-9 | Phenotypic transformation, migration |
RUNX2 | ↑ | MYOCD, RANKL, osteocalcin, sclerostin, α-SMA, SM22α, ALP, Col IA1 | Phenotypic transformation, calcification |
SLUG | ↑ | COX-2, ABCA1, ABCG1 | Phenotypic transformation, foam cell |
MEF2C | ↓ | – | Proliferation, migration |
HIF-1 | ↑ | MIF | Proliferation, migration |
TR3 | ↑ | p27 | Proliferation |
AP1 | ↑ | cyclin A | Proliferation |