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Fig. 1 | Molecular Medicine

Fig. 1

From: TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre-implantation embryos

Fig. 1

DNA Topoisomerase II Alpha (TOP2A) is expressed in low levels in villus of patients with recurrent spontaneous abortion (RSA) and is associated with RSA. A Immunohistochemical staining of TOP2A (n = 5 in each group) and relative quantitative analysis in the two groups. B Western blotting to assess TOP2A expression at the protein level in patients with RSA (n = 3). C TOP2A expression in villi from patients with RSA and the control group was analysed using qRT-PCR (n = 11). Student’s t-test was used in A–C and data are presented as the mean ± standard error of mean (SEM). **P < 0.01, ***P < 0.001. Scale bar: 100 μm

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Molecular Medicine

ISSN: 1528-3658