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Fig. 3 | Molecular Medicine

Fig. 3

From: Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis

Fig. 3

The effect of KLF3-AS1 on Sirt1 protein expression and its stability. A, B Cells were treated by vector or KLF3-AS1 overexpression plasmid. Sirt1 mRNA and protein levels were determined. C, D Cells transfected with KLF3-AS1 overexpression plasmid or vector were treated with cycloheximide, and Sirt1 protein level were detected. E After transfected with KLF3-AS1 overexpression plasmid or vector, Cells were treated with MG132. And Sirt1 protein level was detected. Values were expressed as mean ± SD of three separate determinations in the in vitro assays. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658