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Fig. 5 | Molecular Medicine

Fig. 5

From: PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling

Fig. 5

PLK1 physically interacts with TANK and inhibits TANK expression in the intestinal epithelium. A PLK1 physically interacted with TANK in Caco-2 cells with or without LPS treatment. B, C The location of PLK1 (green) and TANK (red) in the intestinal epithelium or Caco-2 cells after the indicated treatments. The nuclei are stained blue. The scale bar represents 20 μm. D, E Representative Western blots showing TANK after the indicated treatments in upper area, and the lower graph shows the relative band densities. F, H Representative microphotographs of TANK expression in the intestine after the indicated treatments (scale bar = 20 μm). The graph shows the relative fluorescence intensity. G, I Representative Western blots showing TANK after the indicated treatments in the upper area, and the lower graphs show the relative band densities. The data in the graphs are expressed as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. (n = 6)

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Molecular Medicine

ISSN: 1528-3658