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Fig. 8 | Molecular Medicine

Fig. 8

From: PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling

Fig. 8

Schematic showing the regulatory mechanism of PLK1/TANK/NF-κB signalling in sepsis-induced intestinal barrier dysfunction. Sepsis/LPS downregulates PLK1 expression in the intestinal epithelium, weakening the inhibitory effect of PLK1 on TANK and increasing TANK expression, which subsequently activates NF-κB signalling. Activated NF-κB disrupts the balance in mitochondrial dynamics, destroys mitochondrial function through increased ROS production, induces apoptosis in the intestinal epithelium and ultimately leads to intestinal barrier damage.

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Molecular Medicine

ISSN: 1528-3658