Fig. 4

LINC00963 crucially enhanced tumor metastasis in vivo. A549 cells with LINC00963 overexpression or silence were injected intravenously into nude mice. A The weights of lung tissues were measured between indicated groups of mice. B Photographs were taken on lung tissues from indicated groups. C The number of lung metastatic nodules was analyzed between indicated groups of mice. D The HE staining was performed on lung tissues from indicated groups. Scale bar: 100 μm. E The overall survival was compared between indicated groups using Kaplan–Meier method. F LINC00963 level was measured by RT-qPCR in lung tissues from indicated groups. **P < 0.01 and ***P < 0.001