Fig. 1

The association of ACK1 with autophagy and the prognostic accuracy of the risk signature of ACK1-related autophagy genes in the TCGA-LUAD cohort. A RNA-seq was performed to examine RNA expression profilings in shControl and shACK1 A549 cells. Differentially expressed genes were enriched in autophagy. The LASSO regression model was used to identify ACK1-correlated autophagy genes contributing most to prognosis and built the best risk signature in the TCGA-LUAD cohort. B The 5-year ROC curves with the risk score show a higher AUC value than other single risk factors. C The Kaplan–Meier survival curves indicated overall survival for low- and high-risk LUAD patients defined by the risk signature. D The relation between the risk score and survival status of the TCGA-LUAD patients. Forest plots of univariate E and multivariate F Cox regression analyses