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Fig. 7 | Molecular Medicine

Fig. 7

From: Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1

Fig. 7

AMPK inhibitor compound C (CC, 20 μM) and shPRKAA1 reinforced the cytotoxic effects of AIM-100 (20 μM) on A549 cells. A A CCK8 assay for A549 cells treated with AIM-100, CC, or both agents for 48 h. B Impacts of AIM-100, shPRKAA1, or combined treatments on the proliferation of A549 cells). C The colony formation assay was adopted to estimate the influences of indicated treatments on A549 cell proliferation. Colony formation was estimated after cells were treated for ten days. D–G Wound-healing (D, E) and transwell migration assays (F, G) were used to check the effects of indicated treatments on A549 cells’ migration abilities, which were evaluated after cells were treated with indicated agents for 18 h. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658