Table 2 Comparison of performance of the SES models with different hyperparameters in the development dataset
|  | p-value = 0.05 | p-value = 0.03 | p-value = 0.01 |
|---|---|---|---|
Cerebellum samples | |||
Separation of ALS (both C9orf72-related familial ALS and sporadic ALS) from healthy samples | |||
10 models | 74.11% | 81.48% | 77.77% |
5 models | 66.66% | 81.48% | 85.18% |
3 models | 74.88% | 77.77% | 70.37% |
Separation of C9orf72-related familial ALS from healthy samples | |||
10 models | 50.00% | 33.33% | 66.66% |
5 models | 72.22% | 66.66% | 83.33% |
3 models | 72.22% | 72.22% | 66.66% |
Separation of sporadic ALS from healthy samples | |||
10 models | 33.33% | 22.22% | 38,88% |
5 models | 33.33% | 22.22% | 44.44% |
3 models | 33.33% | 22.22% | 33.33% |
Frontal Cortex samples | |||
Separation of ALS (both C9orf72-related familial ALS and sporadic ALS) from healthy samples | |||
10 models | 48.14% | 51.85% | 51.85% |
5 models | 51.85% | 51.85% | 55.55% |
3 models | 51.85% | 48.14% | 55.55% |
Separation of C9orf72-related familial ALS from healthy samples | |||
10 models | 61.11% | 72.22% | 38.88% |
5 models | 61.11% | 55.55% | 44.44% |
3 models | 55.55% | 50.00% | 50.00% |
Separation of sporadic ALS from healthy samples | |||
10 models | 61.11% | 61.11% | 61.11% |
5 models | 55.55% | 61.11% | 55.55% |
3 models | 55.55% | 55.55% | 50.00% |