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Fig. 7 | Molecular Medicine

Fig. 7

From: Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner

Fig. 7

METTL3 affected the expression of TMBIM6 by regulating TMBIM6 mRNA stability via YTHDF2 involvement. A–C The knockdown efficiency of different sh-YTHDF2s determined by qRT-PCR and WB. D The relative expression levels of the TMBIM6 mRNA in sh-Con and sh-YTHDF2 group determined by qRT-PCR. E–H Representative WB images and densitometry quantification of TMBIM6 in different groups. The data were normalized to β-actin. I, J Transcript stability assay of TMBIM6 in different groups. n = 3. ns: no significance, *p < 0.05, **p < 0.01, ***p < 0.001

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Molecular Medicine

ISSN: 1528-3658