Fig. 5
From: An engineered miRNA PS-OMe miR130 inhibits acute lung injury by targeting eCIRP in sepsis
PS-OMe miR130 decreases lung inflammation and neutrophil infiltration. Lung tissue was collected for sham, vehicle (veh), and PS-OMe miR130 (miR) treated mice at 20 h after CLP. mRNA levels of A TNF-α, B IL-6, and C IL-1β, were measured by RT-qPCR. mRNA levels for D KC and E MIP-2 were assessed to determine chemokine expression in lung tissue. F Myeloperoxidase (MPO) activity was assessed spectrophotometrically. (n = 8–9/group). For C data expressed as means ± SEM and compared by Kruskal–Wallis test with Dunn’s method (*P ≤ 0.05 versus sham; #P ≤ 0.05 vs. veh). All other data expressed as means ± SEM and compared by one-way ANOVA and SNK method (*P ≤ 0.05 versus sham; #P ≤ 0.05 vs. veh)