Fig. 8
From: An engineered miRNA PS-OMe miR130 inhibits acute lung injury by targeting eCIRP in sepsis
Schematic showing the engineered PS-OMe miR130 and its proposed mechanism for protection in sepsis. The modified miRNA 130b-3p mimic named PS-OMe miR130 binds to eCIRP and blocks eCIRP binding to TLR4. During sepsis, PS-OMe miR130 acts to block the interaction between eCIRP and its receptor TLR4, thereby attenuating inflammatory cytokine release and preventing acute lung injury