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Fig. 2 | Molecular Medicine

Fig. 2

From: Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation

Fig. 2

Establishment of EP300 knockdown bladder cancer cell lines. A EP300 protein level in T24 and TCC-SUP cell lines after transfection of EP300 shRNAs. B, C EP300 mRNA expression level after knockdown of EP300 in T24 and TCC-SUP. D Diagrams of EP300 knockdown strategy. Two shRNAs target endogenous EP300 3’UTR without targeting exogenous EP300 constructs. E Exogenous EP300-wt and EP300-R1627W are efficiently and equally expressed in T24-EP300kd cells

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Molecular Medicine

ISSN: 1528-3658