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Fig. 2 | Molecular Medicine

Fig. 2

From: 2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

Fig. 2

High expression of MYC in osteosarcoma patients: A, B The MNNG/HOS cells were treated with 100 μmol/L of HMA. After treatment, the cells were collected and subjected to RNA-sequencing analysis. Treatment with 0, 50, 100, and 200 μmol/L of HMA was conducted to detect MYC expression level in the OS cells by C PCR and D Western blot. E mRNA of MYC in OS patients. F MYC IHC staining of the OS and bone tissues microarray and G analysis of the IHC scores. H, I IHC staining and Western blotting for MYC of the tumor and tumor-adjacent normal tissue specimens. J, K Survival curve in OS patients

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Molecular Medicine

ISSN: 1528-3658