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Fig. 3 | Molecular Medicine

Fig. 3

From: 2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

Fig. 3

Involvement of MYC in the anti-OS effect of HMA: The OS cell lines were transfected with MYC overexpression plasmid and detected using A PCR and B Western blotting. The proliferation capacity of the OS cell lines after transfecting with MYC and HMA treatment was detected using C CCK-8 assay and D colony formation assay. The OS cell lines were transfected with si-MYC and detected using E PCR and F Western blotting. The proliferation capacity of the OS cell lines after transfecting with si-MYC and HMA treatment was detected using G CCK-8 assay and H colony formation assay. I MNNG/HOS cells were transfected with si-MYC and then injected subcutaneously into the nude mice for xenografts assay. J The tumor growth curve and (K) excised tumor mass as indicated

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Molecular Medicine

ISSN: 1528-3658