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Fig. 4 | Molecular Medicine

Fig. 4

From: 2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

Fig. 4

Impairment of the RAD51-mediated homologous recombination after HMA treatment: A The IC50 of RI-1 was detected in the MNNG/HOS cells with or without HMA treatment. B, C The expression of RAD51 and p-RAD51 was detected. D The subcellular structural localization of H2A.X was detected using immunofluorescence after RI-1 and HMA treatment. After treatment with RS-1 and HMA, the cells were analyzed using E CCK-8 assay and F H2A.X immunofluorescence. G, H Rescue assays show the relationship between HMA, MYC, and RAD51

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Molecular Medicine

ISSN: 1528-3658