Fig. 3

The protective effect of IPA on the IL-1β-induced ECM degradation. A–E RT-qPCR analysis of MMP-3, MMP-13, ADAMTS-5, collagen-II and aggrecan (n = 9). F–H Immunofluorescence and semi-quantitative analysis of collagen-II and aggrecan (n = 5, scale bar = 100 μm, ×200). I–L Western blot and semi-quantitative analysis of MMP-3, MMP-13 and ADAMTS-5 (n = 3). ^*p < 0.05, ^**p < 0.01 vs. the control group, ^#p < 0.05, ^##p < 0.01 vs. the IL-1β group