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Fig. 6 | Molecular Medicine

Fig. 6

From: RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4

Fig. 6

RBM15 regulates insulin sensitivity through m6A-guided inhabitation of CLDN4. a The heatmap of top 10 genes with differentially m6A peaks and differentially expression; b the mRNA of CLDN4 after knockdown and overexpression of RBM15; c IGV analysis for m6A abundance on CLDN4 mRNA in offspring liver of GDM or control; d the Merip-qPCR of CLDN4 after knockdown of RBM15; e glucose uptake test of LO2 cell lines transferred with siCLDN4 (P > 0.05 by ANOVA); f LO2 cells were transfected with CLDN4 siRNA followed with or without 100 nmol/L insulin stimulation for 30 min, PI3K, p-AKT, and p-ERK protein and their total protein levels were determined by Western blot

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Molecular Medicine

ISSN: 1528-3658