Fig. 2
From: Role and mechanism of CD90+ fibroblasts in inflammatory diseases and malignant tumors
CD90+ fibroblasts induce angiogenesis in tumor microenvironment. Human CD90+ fibroblasts participate in angiogenesis of melanoma cells by secreting type I collagen. In colorectal cancer, chemokine ligand 5 (CCL5) positively regulates the expression of solute carrier family member (SLC25A24) in CD90+ fibroblasts, activates pAkt-pmTOR signaling, thus increasing the number of CD90+ fibroblasts, and promotes tumor angiogenesis by enhancing VEGFA expression and transdifferentiating fibroblasts into vascular endothelial cells. In esophageal carcinoma, CD90+ fibroblasts induce the up-regulation of angiogenesis-related genes