Fig. 6

IRF1-exosome facilitates wound healing in DM rats. A The expression of IRF1 and miR-16-5p in rASCs treated with exosomes or IRF1-exosome determined by RT-qPCR. B The expression of IRF1 and miR-16-5p in foot wound tissues of rats on day 14 determined by RT-qPCR. C Wound diameter changes in rats on day 14. D Morphological and structural changes of rat wound tissues observed on day 14 by HE staining. E Collagen deposition in the rat wound tissues analyzed on day 14 by Masson staining. F Quantitative analysis of newly formed (left) and mature (right) blood vessels in rat wound tissues on day 14. *p < 0.05 vs. PBS-treated DM rats. #p < 0.05 vs. exosome-treated rats. Cell experiments were repeated three times. n = 8. Measurement data were presented as mean ± standard deviation. Data among multiple groups were compared by one-way ANOVA, followed by Tukey’s post hoc test for multiple comparisons