Fig. 8

IRF1-exosome loaded into the rASC sheet promotes wound healing in DM rats. DM rats were implanted with rASC sheet or IRF1-rASC sheet at the wound. A Wound healing rate of rats on day 7 and day 14. *p < 0.05 vs. control rats at the same timepoints. B Morphological and structural changes of rat wound tissues observed on day 14 by HE staining. C Collagen deposition in the rat wound tissues analyzed on day 14 by Masson staining. D Quantitative analysis of newly formed (left) and mature (right) blood vessels in rat wound tissues on day 14. *p < 0.05 vs. control rats. E Expression of IRF1, miR-16-5p and SP5 in rat wound tissues detected on day 14 by RT-qPCR. *p < 0.05 vs. control rats. n = 8. Data among multiple groups were compared by one-way ANOVA, followed by Tukey’s post hoc test for multiple comparisons. Repeated measures ANOVA with Tukey’s post hoc test was applied for the comparison of data at different time points