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Fig. 6 | Molecular Medicine

Fig. 6

From: LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter

Fig. 6

GAS5 facilitated H3K4me2/3 demethylation to downregulate PDGFRα/β by recruiting KDM5B. A The binding between H3K4me2/3 and the PDGFR α/β promoter was confirmed by ChIP assay. B The protein levels of KDM5B and H3K4me2/3 after KDM5B knockdown or overexpression were detected via Western blotting. C ChIP assay analysis of the binding between H3K4me2/3 and the PDGFR α/β promoter in KDM5B-silenced or KDM5B-overexpressed pericytes. D The interaction between H3K4me2/3 and the PDGFR α/β promoter after GAS5 silencing or overexpression was determined via ChIP assay. For A–D, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658