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Fig. 8 | Molecular Medicine

Fig. 8

From: LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter

Fig. 8

GAS5 inhibited pulmonary fibrosis in the mouse model of pulmonary fibrosis in vivo. There were six experimental groups: control, bleomycin, bleomycin + NC, bleomycin + GAS5, bleomycin + shNC, and bleomycin + shGAS5. A, B The degree of pulmonary fibrosis and collagen deposition in the lungs of mice was assessed via H&E and Masson staining. C The expressions of desmin, α-SMA, and collagen I in the lung tissues were determined via immunohistochemical staining. D RT-qPCR analysis of GAS5 expression in different groups. E The protein levels of desmin, NG-2, α-SMA, collagen I, KDM5B, and PDGFR α/β in the lungs were examined via Western blotting. For A–E, n = 6. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658