Fig. 6

Effect of BMP7 on the IDD of T1DM rats by regulating NLRP3 inflammasome activity and pyroptosis of NPCs. A BMP7 expression in the transcriptome sequencing data of T1DM-induced IDD rats. Control (normal rats) n = 3, STZ (T1DM-induced IDD rats) n = 3. B BMP7 expression in the NP tissues of STZ-induced T1DM rats measured by RT-qPCR. C BMP7 expression in the NPCs isolated from STZ-induced T1DM rats measured by RT-qPCR. D Levels of pyroptosis-related proteins in NPCs and cell supernatant measured by ELISA. E BMP7 expression in NPCs from STZ-induced T1DM rats transduced with oe-BMP7 and treated with 4’MR determined by RT-qPCR. F BMP7 levels in NPCs and cell supernatant from STZ-induced T1DM rats transduced with oe-BMP7 and treated with 4’MR measured by ELISA. G Levels of pyroptosis-related proteins in NPCs from STZ-induced T1DM rats transduced with oe-BMP7 and treated with 4’MR measured by ELISA. n = 12. *p < 0.05. n.s. indicates not significant. Data are shown as the mean ± standard deviation. Data between two groups were compared by unpaired t-test, and data comparisons among multiple groups were analyzed by the one-way ANOVA with Tukey’s post hoc test. The cell experiment was repeated three times independently