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Fig. 7 | Molecular Medicine

Fig. 7

From: BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity

Fig. 7

BMP7 affects the IDD of T1DM rats by regulating NLRP3 inflammasome activity and NPC pyroptosis. STZ-induced T1DM rats were treated with oe-BMP7 alone or combined with 4’MR (n = 12). A Measurement of disc height of STZ-induced T1DM rats. B HE staining of NP tissues from STZ-induced T1DM rats. C Safranin O-fast green staining for NP tissues and AF tissues of STZ-induced T1DM rats. D ECM-related gene expression in NP tissues from STZ-induced T1DM rats. E BMP7 expression in NP tissues of STZ-induced T1DM rats determined by RT-qPCR. F BMP7 levels in NP tissues of STZ-induced T1DM rats measured by ELISA. G Levels of pyroptosis-related proteins in NP tissues of STZ-induced T1DM rats measured by ELISA. H Apoptosis in NP tissues of STZ-induced T1DM rats detected by TUNEL staining. I Ki67-positive cells in NP tissues of STZ-induced T1DM rats detected by IHC. *p < 0.05. Data are shown as the mean ± standard deviation. Data comparisons among multiple groups were analyzed by one-way ANOVA with Tukey’s post hoc test

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Molecular Medicine

ISSN: 1528-3658