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Fig. 2 | Molecular Medicine

Fig. 2

From: Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification

Fig. 2

KuA significantly improved the tibia bone microstructure and mechanical properties in OVX mice. A Representative figure in the tibia. B BV/TV of the tibia. C Tb.N of tibia. D Tb.Sp of the tibia. E Tb.Th of the tibia. These results found that KUA improved the bone microstructure of the tibia in ovariectomized mice. F, G The maximum force of the tibia. Mechanical results showed that KUA improve the maximum stress of the tibia in ovariectomized mice. The bar is 0.7 mm. *P < 0.05, **P < 0.01,***P < 0.001,****P < 0.0001. KuA: Kukoamine A; OVX: ovariotomy; L4: Lumber 4; BMD: bone mineral density. BV/TV: bone volume over total volume; Tb.Th: trabecular thickness; Tb.N: trabecular number, Tb.Sp: trabecular spacing

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Molecular Medicine

ISSN: 1528-3658