Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification

Table 5 Topological analysis results by degree—the first 20 proteins

Gene names	Annotation	Closeness centrality	Degree
NTRK1	Neurotrophic receptor tyrosine kinase 1	0.582762	218
MCM2	Minichromosome maintenance complex component 2	0.574324	210
CUL3	Cullin 3	0.557638	197
NPM1	Nucleophosmin	0.555556	181
FN1	Fibronectin 1	0.555037	188
HNRNPU	Heterogeneous nuclear ribonucleoprotein U	0.5494	170
ESR1	Estrogen receptor 1	0.537975	167
CDK2	Cyclin dependent kinase 2	0.537975	154
RPS11	Ribosomal protein S11	0.534591	171
RPS3A	Ribosomal protein S3A	0.534111	148
ITGA4	Integrin subunit alpha 4	0.533632	164
RPS3	Ribosomal protein S3	0.533632	150
CAND1	Cullin associated and neddylation Dissociated 1	0.533154	165
RPS4X	Ribosomal protein S4, X-linked	0.530303	144
COPS5	COP9 signalosome subunit 5	0.524691	148
RPS14	Ribosomal protein S14	0.524691	146
RPS16	Ribosomal protein S16	0.524229	143
VCAM1	Vascular cell adhesion molecule 1	0.523307	146
CUL1	Cullin 1	0.519197	153
ICAM1	Intercellular adhesion molecule 1	0.510292	161

ISSN: 1528-3658