Fig. 7
From: Caveolin-1 is involved in fatty infiltration and bone-tendon healing of rotator cuff tear
GATA6 suppresses fatty infiltration after RCT in rats by diminishing Caveolin-1 expression and activating the cAMP/PKA pathway. RCT rats were treated with oe-GATA6 + oe-NC, oe-GATA6 + oe-Caveolin-1 and oe-GATA6 + oe-Caveolin-1 + forskolin. A Expression of GATA6, Caveolin-1, PKA, and CREB in the supraspinatus tendon of RCT rats measured by RT-qPCR. B Western blot of GATA6, Caveolin-1, PKA, pPKA, CREB, and pCREB proteins in the supraspinatus tendon of RCT rats. C Fatty infiltration of supraspinatus tendon of RCT rats evaluated by oil red O staining. D Western blot of lipolysis-related proteins (ATGL and pHSL/HSL) in the supraspinatus tendon of RCT rats. E Western blot of adipogenesis-related proteins (FAS, PPAR-γPAand pACC/ACC) in the supraspinatus tendon of RCT rats. n = 8 rats for each treatment. *p < 0.05, compared with the RCT rats treated with oe-NC. #p < 0.05, compared with the RCT rats treated with oe-GATA6 + oe-NC. &p < 0.05, compared with the RCT rats treated with oe-GATA6 + oe-Caveolin-1