Fig. 8
From: Caveolin-1 is involved in fatty infiltration and bone-tendon healing of rotator cuff tear
GATA6 regulates Caveolin-1/cAMP/PKA axis to promote bone-tendon healing, improve biomechanical properties, and reduce the rupture risk of injured tendon after RCT in rats. RCT rats were treated with oe-GATA6 + oe-NC, oe-GATA6 + oe-Caveolin-1 and oe-GATA6 + oe-Caveolin-1 + forskolin. A HE staining of the bone-tendon junction of RCT rats. B Shows the bone, M represents muscle, and T represents tendon. B Masson’s trichrome staining of the density of substrate and continuity of collagen fibers in RCT rats. C Immunohistochemistry of collagen I positive (brown) expression of RCT rats. D Quantitative analysis of panel C. E The maximum load of RCT rats measured by biomechanical test. F The limiting stress of RCT rats measured by biomechanical test. G The fracture elongation rate of RCT rats measured by biomechanical test. n = 8 rats for each treatment. *p < 0.05, compared with the RCT rats treated with oe-NC. #p < 0.05, compared with the RCT rats treated with oe-GATA6 + oe-NC. &p < 0.05, compared with the RCT rats treated with oe-GATA6 + oe-Caveolin-1