Fig. 1

EMT Signaling is closely related to chronic low-grade inflammation in OA synovium

(A-B) Western blot (A) and immunohistochemical staining (B) of N-cadherin in OA and Non-OA synovium. Red dashed lines (A, right) divide the patients into high (red) and low (black and green) subpopulations according to their N-CDH levels (n = 3, bar = 100 μm). (C) A heatmap for the mRNA expression of several common inflammatory factors in the non-OA, N-CDH⁻ and N-CDH⁺ OA subpopulations (n = 3). (D) Western blot of EMT markers and several positive inflammatory factors in (C). (E) The expression level and position of N-cadherin (green) and MMP13 (red) in the synovium of the N-CDH⁻ and N-CDH⁺ OA subpopulations (bar = 100 μm)