Fig. 8

STAT1 targeted MALAT1 to promote its transcription. A STAT1 expression levels of the mice were assessed by RT-qPCR 72 h after the indicated treatments. B The binding sites between MALAT1 and STAT1 was showed. C–E The luciferase activities of the BV2 cells 24 h after transfection of the luciferase reporter vectors. Sequences of three STAT1 sites were cloned into the vectors, respectively. F MALAT1 enrichments of the three STAT1 sites were detected by RIP assay. The MALAT1 relative enrichment was normalized to input. G MALAT1 expression levels of the BV2 cells 72 h after the indicated treatment. (n = 3), ^**P < 0.01