Fig. 1
From: RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
Osteosclerosis phenotype in RhoA-CKO mice. a, c Tibias of 3-month-old RhoAf/f and RhoA CKO mice were imaged using a Micro-CT scanner. b, d The parameters of tibias growth plate trabecular bone. n = 6, BMD, bone mineral density; BV/TV, bone volume as a fraction of total bone volume; Tb.Th, trabecular thickness; Tb.No, trabecular number; Tb.Sp, trabecular separation. e, h TRAP and H&E staining images of mice femurs. Scale bars, 200 µm (H&E) and 20 µm (TRAP). f, i The parameters of femur osteoclasts. n = 6, ES/BS, eroded surface per bone surface; Oc.S/BS, osteoclast surface per bone surface; and N.Oc/BS, osteoclast number per bone surface. g, j Serum TRAP5b and CTX-1 levels, n = 6. Mean ± s.d., *P < 0.05, **P < 0.01, Student’s t-test