Fig. 5
From: miR-34a-5p as molecular hub of pathomechanisms in Huntington’s disease
Overview of the KEGG “Huntington’s Disease Signaling Pathway” with new direct miR-34a-5p target genes. A Impact of miR-34a deregulation on the subcategories “glutamatergic synapse”, “calcium signaling”, “transcriptional activation”, “mitochondrial dysfunction”, “ER stress” and “apoptosis”. Direct target genes of miR-34a-5p are marked in green. All marked target genes were identified by our group. Target genes with no asterisk were identified in this study. Target genes with asterisks were identified in recent studies as indicated in the diagram (Kern et al. 2021; Diener et al. 2018; Krammes et al. 2020). B Impact of miR-34a deregulation on the subcategories “endocytosis”, “vesicular transport”, “transcriptional repression”, “respiration”, “protein folding” and “apoptosis”. Direct target genes of miR-34a-5p are marked in green. All marked target genes were identified by our group. Target genes with no asterisk were identified in this study. Target genes with one asterisk were identified in a recent study as indicated in the diagram (Kern et al. 2021)