Fig. 2

RIPK2 was screened out as a key protein kinase in pancreatic cancer. A protein–protein interaction analysis with physical connection (p < 1.0e−16, the highest confidence of 0.9) based on the DEGs. The kinase-encoding genes were marked in yellow and their links in red. B Venn diagram indicating the differentially expressed protein kinases. C Spearman correlation analysis of the RIPK2 and PRKCI expression in both normal pancreas and pancreatic cancer through GEPIA database (R = 0.86, p = 3.1e−102). D RIPK2 protein expression between pancreatic cancer and normal pancreas by immunohistochemistry in the Human Protein Atlas. E–G RIPK2 mRNA expression between pancreatic cancer and normal tissue based on TCGA and GEO databases. H, I Survival analysis of RIPK2 in pancreatic cancer patients based on TCGA and GEO databases. ^*p < 0.05, ^***p < 0.001