Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation

Table 1 Seventeen differentially expressed protein kinases in pancreatic cancer

No	Gene symbol	Gene name	Type	Expression^a (T vs. N)	OS^b (p value)
1	BMPR2	Bone morphogenetic protein receptor type 2	Serine/threonine kinase	High	0.58
2	BUB1	BUB1 mitotic checkpoint serine/threonine kinase	Serine/threonine kinase	High	0.0033
3	CDK1	Cyclin dependent kinase 1	Serine/threonine kinase	High	0.0006
4	EPHA3	EPH receptor A3	Tyrosine kinase	High	0.66
5	EPHA4	EPH receptor A4	Tyrosine kinase	High	0.52
6	EPHB2	EPH receptor B2	Tyrosine kinase	High	0.3
7	INSR	Insulin receptor	Tyrosine kinase	NS	0.57
8	MET	MET proto-oncogene	Tyrosine kinase	High	0.00023
9	NEK6	NIMA related kinase 6	Serine/threonine kinase	High	0.29
10	PAK1	P21(RAC1) activated kinase 1	Serine/threonine kinase	High	0.048
11	PAK3	P21(RAC1) activated kinase 3	Serine/threonine kinase	Low	0.25
12	PRKCI	Protein kinase C iota	Serine/threonine kinase	High	0.00063
13	RIPK2	Receptor interacting Serine/threonine kinase 2	Serine/threonine/tyrosine kinase	High	0.0025
14	NEK2	NIMA related kinase 2	Serine-threonine kinase	High	0.0038
15	LYN	LYN proto-oncogene	Tyrosine kinase	High	0.15
16	FGFR1	Fibroblast growth factor receptor 1	Tyrosine kinase	NS	0.028
17	NEK9	NIMA related kinase 9	Serine/threonine kinase	NS	0.049

^aGene expression comparison between Tumor and the normal (T vs. N); ^b overall survival analysis based on TCGA database

ISSN: 1528-3658