Skip to main content
Fig. 3 | Molecular Medicine

Fig. 3

From: Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway

Fig. 3

Myoblast-derived exosomal Prrx-2 increases transcriptional activity of lncRNA-MIR22HG in BMSCs. (A) qRT-PCR analysis of MIR22HG expression in BMSCs from the PM, OM, OM + Exo-shNC, OM + Exo-shPrrx-2 groups. (B) JASPAR database analysis of the binding sites of Prrx-2 in MIR22HG promoter. (C) ChIP and (D) Dual-luciferase reporter assays were adopted to validate the direct binding of Prrx-2 in MIR22HG promoter. * P < 0.05, ** P < 0.01 and *** P < 0.001

Back to article page

Molecular Medicine

ISSN: 1528-3658