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Fig. 4 | Molecular Medicine

Fig. 4

From: Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway

Fig. 4

Silencing of Prrx-2 in myoblast-derived exosomes represses osteogenic differentiation via inhibiting MIR22HG expression. (A) MIR22HG expression in BMSCs fromVector, MIR22HG, shNC and shMIR22HG groups was assessed by qRT-PCR. (B) The matrix mineralization of BMSCs from OM, OM + Exo-shNC, OM + Exo-shPrrx-2, OM + Exo-shPrrx-2 + vector, OM + Exo-shPrrx-2 + MIR22HG groups was determined by Alizarin Red staining. (C) The ALP activity of BMSCs from different groups. (D-I) The mRNA and protein level of OCN, BMP2, OPN, and RUNX2 was analyzed by qRT-PCR and Western blotting. * P < 0.05, ** P < 0.01 and *** P < 0.001

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Molecular Medicine

ISSN: 1528-3658