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Fig. 5 | Molecular Medicine

Fig. 5

From: Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway

Fig. 5

MIR22HG sponges miR-128 to activate YAP signaling pathway. (A) Starbase database predicted the binding sites of MIR22HG in miR-128. (B) RIP and (C) Dual-luciferase reporter assays confirmed the interaction between MIR22HG and miR-128. (D) miR-128 and (E) YAP1 mRNA levels in BMSCs from PM, OM, OM + shNC, OM + shMIR22HG were determined by qRT-PCR. (F&G) Western blotting analysis of YAP1 protein levels in BMSCs with various treatments. (H) The subcellular distribution of YAP1 in BMSCs was evaluated by immunofluorescence staining. ** P < 0.01 and *** P < 0.001

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Molecular Medicine

ISSN: 1528-3658