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Fig. 1 | Molecular Medicine

Fig. 1

From: ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response

Fig. 1

Increased ATF5/HSP60/LONP1 expression positively correlates with tubulointerstitial damage in kidney biopsy sections of DKD patients. A HE, PAS and Masson staining of the histological changes in kidney biopsies of DKD patients. B, C Quantitative analysis of interstitial fibrosis and tubular atrophy (IFTA) scores and glomerular injury. D IHC staining of ATF5/HSP60/LONP1, C-CAS3 and FN in kidney biopsy sections of DKD patients. E1–E3 The correlations of ATF5, HSP60 and LONP1 expression levels with IFTA scores. E4–E5 The correlations of HSP60, LONP1 with ATF5 expression in the kidney of type 2 DKD patients. Scale bar: 25 μm. All data are presented as means ± SD; *p < 0 .05 vs control group. r: correlation coefficient. n = 10

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Molecular Medicine

ISSN: 1528-3658