Fig. 1
From: TRIM37 exacerbates hepatic ischemia/reperfusion injury by facilitating IKKγ translocation
Inhibition of TRIM37 relieved hepatic I/R injury. A TRIM37 expression was upregulated in vitro. B, C Protein expression of the TRIM37, MAPK and IKK pathways was increased in vivo. D, E Interference of TRIM37 alleviated hepatic pathological injury and apoptosis in hepatic I/R injury. Scale bar = 200 μm for HE, scale bar = 100 μm for TUNEL. F, G Liver enzymes and cytokines in mouse serum after inhibiting TRIM37 in hepatic I/R injury. H, I Immunofluorescence analysis of p65, F4/80, TRAF6 and TRIM37 in primary Kupffer cells after hepatic I/R injury. Scale bar = 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001, N.Sp > 0.05, n = 5–6 for each group, the two lanes in a row are from the same mixed samples