Fig. 2
From: TRIM37 exacerbates hepatic ischemia/reperfusion injury by facilitating IKKγ translocation
TRIM37 reinforced IKK instead of ASK1/MAPK. A–E TRIM37 knockdown augmented the expression of cytokines and chemokines in primary Kupffer cells after H/R treatment. F Inhibition of TRIM37 weakened IL-6 but not p-ASK1 protein expression. G MAPK pathway proteins were hardly altered by TRIM37 deficiency. H The IKKβ/IKK complex was significantly suppressed when TRIM37 expression was restricted in vitro. I The phosphorylation of TAK1/IκBα/NF-κB p65 was reduced by TRIM37 repression. Two lanes in a row are from the same mixed samples. All in vitro experiments were repeated at least 3 times. *p < 0.05, **p < 0.01, N.Sp > 0.05