Fig. 3
From: TRIM37 exacerbates hepatic ischemia/reperfusion injury by facilitating IKKγ translocation
Enrichment of TRIM37 exacerbated hepatic I/R injury. A Overexpression of TRIM37 aggravated hepatic pathological injury and apoptosis in vivo. Scale bar = 200 μm for HE, scale bar = 100 μm for TUNEL. B TRIM37 increased serum cytokines and chemokines in mice. C Immunofluorescence analysis of p65 and F4/80 in primary Kupffer cells after I/R treatment. Scale bar = 50 μm for immunofluorescence. D Protein expression of TRIM37 and the MAPK pathway after TRIM37 enrichment in vivo. E Protein expression of the IKK pathway after TRIM37 enrichment in vivo. F The activation of TAK1/IκBα/NF-κB p65 after TRIM37 enrichment in vivo. *p < 0.05, **p < 0.01, ***p < 0.001, the two lanes in a row are from the same mixed samples, n = 5–6 for each group