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Fig. 8 | Molecular Medicine

Fig. 8

From: CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

Fig. 8

Enarodustat alleviated renal injury aggravated by Cirp knockout in rats undergoing DHCA. A, B Western blot analyses of CIRP, PHD3, HIF-1α, Bax, Bcl-2, caspase 9 and cleaved caspase 9, FADD, caspase 8 and cleaved caspase 8, caspase 3 and cleaved caspase 3 and β-actin of rats in the DHCA, DHCA + Cirp−/− and DHCA + Cirp−/− + Enarodustat groups. C Representative H&E staining images of the renal cortex and medulla in the DHCA, DHCA + Cirp−/− and DHCA + Cirp−/− + Enarodustat groups (original magnification, × 200). D Pathological lesion score of renal samples from three groups. Statistical significance was examined by one-way analysis of variance (ANOVA) followed by the Tukey test. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658