Fig. 5
From: Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation
Inhibition of p38 MAPK kinase prevents the profibrotic effect of Nr4a1 in HK-2 cells (A) Western blot analysis and (B) corresponding quantitative analysis of p38 MAPK phosphorylation in HK-2 cells with or without Nr4a1 siRNA expression and TGF-β1 treatment. (C) Western blot analysis and (D) corresponding quantitative analysis of p38 phosphorylation level in HK-2 cells with or without Csn-B treatment. (E) Western blot analysis and (F) corresponding quantitative analysis of Fn and Col-I in HK-2 treated with Csn-B and p38 inhibitor. One-way analysis of variance (ANOVA), followed by Tukey’s post-tests, was used to compare the statistical differences among multiple groups. *p<0.05, **p<0.01, ***p<0.001