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Table 1 Patient clinical characteristics

From: Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor

Characteristics

SALI

SNALI

P

Number of patients included (n)

15

15

 

Age (years)

64.7 (39–86)

58.6 (23–79)

0.294

Males (n)

12 (80.00)

9 (60.0 )

0.24

SOFA

11 (8–14)

5 (4–6)

0.005

Laboratory

   

BUN (mg/dL)

14.43 ± 2.94

14.16 (-1.16-29.49)

0.971

Cr (umol/L)

219.2 (143.2-295.2)

92.67 (60.3-125.1)

0.004

ALT (U/L)

128.6 (77.1-180.1)

13.9 (9.6–18.1)

0.0003

AST (U/L)

274.7 (128.2-428.1)

16.7 (12.3–21.1)

0.002

Bilirubin (µmol/L)

25.3 (13.9–36.8)

15.2 (8.8–17.5)

0.047

Clinical Outcomes

   

Mortality within 28 days (n/%)

6 (40.00)

1 (6.67)

0.031

hospitalization time (d)

17.3 ± 6.93

11.2 ± 3.58

0.024

  1. SALI, sepsis-associated acute liver injury; SNALI, sepsis without acute liver injury; SOFA, sequential organ failure assessment; BUN, blood urea nitrogen; ALT, Alanine transaminase; AST, Aspartate transamina